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- This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis.
- Original Article. Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection. Najib M. Rahman, D.Phil., Nicholas A. Maskell, D.M., Alex West, M.R.C.P., Richard Teoh, M.R.C.P., Anthony Arnold, M.R.C.P.
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Original Article. Tissue Plasminogen Activator for Acute Ischemic Stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group * N Engl J Med 1995; 333:1581-1588 December 14, 1995 DOI: 10.1056. Inherited Causes of Blood Clots. Inherited Causes of Blood Clots. Increased levels of natural procoagulants. Factor V Leiden mutation (APC resistance) Prothrombin 20210 mutation; Hyperhomocysteinemia; FVIII, FIX, FXI, FVII. Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and. This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen. *173360 SERPIN PEPTIDASE INHIBITOR, CLADE E (NEXIN, PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1), MEMBER 1; SERPINE1 Alternative titles; symbols.
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Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease for Pleural Infection. An Effective and Safe Alternative to Surgery. Blood Clotting. When blood vessels are cut or damaged, the loss of blood from the system must be stopped before shock and possible death occur. This is accomplished by solidification of the blood, a process called coagulation. Complications associated with the use of urokinase and recombinant tissue plasminogen activator for catheter-directed peripheral arterial and venous thrombolysis.